Vitamin B6

Biological role



All three forms of vitamin B6 are equally active and act as precursors of coenzyme pyridoxal phosphate. Pyridoxal phosphate is the prosthetic group of a number of enzymes involved in amino acid metabolism (in the processes of phosphorylation, decarboxylation and racemization), metabolism of fats and carbohydrates.

Vitamin B6 is absorbed in the small intestine usually in the form of pyridoxal, which is then converted into pyridoxamine. All three compounds, which are commonly named vitamin B6 serves as a substrate for the enzyme pyridoxal kinase, which uses ATP and phosphorylates it to its corresponding phosphate esters. In addition, this vitamin is essential for the functioning over six enzymes and the smooth synthesis of nucleic acids and proteins.

The important role of this vitamin can be seen in its role in the proliferation of cells and the creation of white blood cells and immune system cells. Vitamin B6 also play a role in the prevention and protection of the body against the introduction of oral contraceptives. Specifically, women who use these medications, there is often a variety of disorders in the metabolism of tryptophan (one of the essential amino acids), and these disorders can be controlled by entering of vitamin B6.

Higher doses of vitamin B6 can be used for removing acne and pimples, and drying of the skin, but after some time with the vitamins in the treatment of skin disorders can lead to the emergence of itching.

It is noted the role of vitamin B6 in the prevention of cataracts.

Pyridoxine is generally excreted by urine.