The biological role of nickel is not yet fully known. Although nickel is generally evenly distributed in the body slightly larger amount is within the nucleic acid, especially in ribonucleic acid (RNA) and it is considered to affect the structure or function of the proteins associated with nucleic acids.
In addition, the role of nickel is associated with enzymes that affect the breakdown and use of glucose, but also in the creation of prolactin (and thus the production of milk in the mammary glands).
Enzymes that use nickel are not identified yet although nickel activates and inhibits enzymes that contain other metals. In addition to its role in enzymes, nickel is involved in the production and action of certain hormones.
Nickel affects optimal growth, healthy skin, bone structure. It is involved in iron metabolism (since it affects the absorption of iron from food) and plays a role in the creation of red blood cells. It is necessary in the metabolism of sugars, fats, hormones and cell membranes.
The majority of studies on the role of nickel in the body are done on animals, so their relevance to humans can not be verified yet.