Vitamin B12 is one of the most complex vitamin by its chemical structure. The history of vitamin B12 studing is closely related to the examination of the causes of anemia and develop methods for its treatment.
In 1926 was found that the inclusion of large amounts of semiraw liver in the food of patients suffering from malignant anemia, showed beneficial effects. Then in 1940 was proven one bacterial species whose growth is dependent on this factor. These bacteria were used as a test in the evaluation of active factors obtained from the liver of animals.
This vitamin has long been viewed as a medical ortodoks and was often accompanied with suspicion and with scorn. A small number of doctors, but many alternative medical, attributed this vitamin claiming to have a significant effect on rejuvenation and is a great source of energy. They claimed that vitamin B12 increases the power of memory, reasoning ability and concentration, ie. treats mental disorders, and generally makes a body younger.
Vitamin B12 affects the better physical condition and rejuvenate the body
Only recently this vitamin began to be viewed as one that is really important in addition to the features described above. Today, for example is known that vitamin B12 is irreplaceable in metabolism of nerve tissue in humans.
The crystalline form of vitamin B12 was obtained in 1948, and only a decade later was determined its structure. Total synthesis of vitamin B12 was made in 1972. This is one of the most complex synthesis in organic chemistry, and the first who were synthesized it were organic chemists K. Woodward from the U.S. and A. Eschenmoser from Switzerland.